Think of your brain as a freeway with millions of neurotransmitters transmitting information from one part of the brain to another with billions of connections between them. In severe and chronic stress, such as depression, your nerve cells lose some of these connections and communication between them becomes insufficient and noisy. Depression occurs as a result of noisy communication between neurons that regulate mood and emotion. Understanding the neuroscience behind depression is essential, as there is a difference between a depressed brain and a healthy brain. The exciting thing is that when you treat depression effectively, the brain looks healthy again. Treatment for depression is a long term process so we need new approaches to treat depression like TMS therapy, Ketamine and biofeedback.